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Alpha-antagonists are the most effective agents used to treat the moderate-to-severe and bothersome symptoms associated with bladder outlet obstruction (BOO) secondary to BPH.

The alpha-antagonists reduce BOO by decreasing the alpha-adrenergic tone of the smooth muscle within the prostate.As symptoms progress, alpha-antagonists are typically the first-line agents due to their efficacy and rapid response seen upon initiation.If symptoms persist despite optimization of alpha-antagonists, or a patient is unable to tolerate side effects related to their use, 5-alpha-reductase inhibitors may be added to the regimen.That particular model with composition headlamps didn't appear until 1986 at least a year before Ron was diagnosed with HIV.A Saab 900 convertible seen in the background during Ron's first visit to Mexico wasn't imported to the United States until 1987 model year.

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